I think there is basically only one major reason that anyone believes this to be impossible... namely, the assumption that genuine understanding requires the acquisition of external ontological information.
Seeing "external ontological information" as being
constructed by humanity, like technology, rather undermines this assumption.
Surely, to whatever extent there can be said to be a "truth of reality", it will not be made any clearer through studying our own somewhat arbitrary creations.
I suggest a better approach is to study the mechanisms by which we experience, investigate, and form conclusions about reality... recognizing that such mechanisms have much power to shape the experience of reality... and furthermore, that any notion of "true reality beneath experience" falls into the category of constructed ideas (or "mental technologies").
Notably, this approach has always been available at every point in history.