Just like child proof bottles. If you have a hard time have a kid open them for you. Lol... I take zolfran for my gastroparesis. It is in a bubble pack but you can not punch them through as it crushes them. You have to tear the blister pack out and them lift the corner of the backing and peel it away. But they only pill it back less than a 1/16" and I have no nails and very diminished dexterity. Nothing like throwing up your guts trying to open this little packet at the same time. I carry a sharp knife for a reason. LolBigAl1 said:I hate the blister packaging. I have a hard time getting a pill out. I looked up why they are packaged that way lately. It's out govt protecting us.