I nominate ilomilo as the cutest video game ever produced.
Although Little Big Planet comes close.
Of course, I could be sarcastic and nominate Manhunt, but what would be the point of that?
Cutest video game characters? Well, saying Ilo and Milo would be a bit too obvious.
Vivi from FFIX. The Tarutarus from FFXI. Link from Twilight Princess. A Boy and His Blob. The Murmur Twins. Sackboy. Karol from Tales of Vesperia. Mega Man. Sora from Kingdom Hearts. All of the heroes in Blue Dragon. The cast of Lego Star Wars.
Of course, I could also add a list of hawt video games characters, but that probably deserves a thread of its own. Just for the record, the only person in my cute list that also makes my hawt list is Link. but that probably has more to do with all of the yaoi doujins I have seen featuring him over the years than anything else.
What makes your list?