In Dollhouse, Dushku plays a young woman named Echo, a member of a group of people known as "Actives" or "Dolls" who have had their personalities wiped clean so they can be imprinted with any number of new personas, including memory, muscle memory, skills, and language, for different assignments. They're then hired out for particular jobs, crimes, fantasies, and occasional good deeds. In between tasks, they are mind-wiped into a child-like state and live in a futuristic dormitory/laboratory, a hidden facility nicknamed "The Dollhouse". The story follows Echo, who begins, in her mind-wiped state, to become self-aware.
Beyond Dushku's character, the show will also revolve around the people who run the mysterious "Dollhouse" and two other "Dolls", Victor and Sierra, a man and woman who are friendly with Echo. Although the Actives are ostensibly volunteers, the operation is highly illegal and under constant threat from Paul Smith, a determined federal agent who has heard a rumor about the dolls on one end and an insane rogue Active on the other.