In the movie "Unfaithful," the couple's 9-year-old son (played by the same kid who played the youngest brother on Malcolm in the Middle) wet his bed.
Family Guy has numerous, numerous references to diapers, potty-training and fecal and urinary incontinence, including the fact that Joe wears adult diapers.
On one of the first episodes of the show "Gilmore Girls," entitled "The Deer Hunters," Lorelai, the mom, explains to her daughter Rory's teacher that at age four Rory was so interested in attending Harvard University that she bought her a Harvard sweatshirt "which of course was way too big for her, so she used it as a blanket for awhile and then as a diaper on this really ill-fated shopping trip and now I've told you a story that would so humiliate her she'll kill me when she finds out you know."
That's probably not the exact quote, but it's close.
"Finding Nemo" has the "awwww...you guys made me ink!" joke with Nemo's squid classmate when he gets scared.
The little boy in Big Daddy wets his bed, and then the same day pees all over Adam Sandler while he's being carried around.
In The Waterboy, also a Sandler film, Adam Sandler's character is revealed to be a bedwetter when the mom doesn't like the girl he's dating - she points to his urine-stained sheets hanging up on the clothesline.
Anyway, that's all I can think of now, but I tend to remember these things so I'll post any more that I can think of.
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